We develop image algorithms to support diagnosis and treatment decisions in stroke. We further aim to simplify the CT imaging protocol by developing new techniques to enable single 4D CT scanning, saving radiation dose, contrast agent and time to diagnosis.

The first algorithms have focused on the segmentation of the main cerebral anatomical structures, including the intra-cavity space, blood vessels, white matter, gray matter and cerebrospinal fluid (see image below, and this interview). We then have shifted our focus on the automated detection of neurovascular pathologies and 3D image reconstruction (such as the non-contrast CT) from a 4D CT acquisition.

Brain tissue and vessel segmentation in 4DCT

Aunt Minnie has extensively covered our work: on intra-cavity segmentation, on wm/gm segmentation and on color-mapping to visualize vascular flow disturbances. The work on intra-cavity segmentation was also covered by SPIE Newsroom.



  • M. Meijs, F.-E. de Leeuw, H.D. Boogaarts, R. Manniesing and F.J.A. Meijer. "Circle of Willis collateral flow in carotid artery occlusion is depicted by 4D-CTA", World Neurosurgery 2018;114:421-426. Abstract/PDF DOI PMID

  • A. Patel and R. Manniesing. "A convolutional neural network for intracranial hemorrhage detection in non-contrast CT", in: Medical Imaging, volume 10575 of Proceedings of the SPIE, 2018. Abstract/PDF DOI

  • S.C. van de Leemput, M. Prokop, B. van Ginneken and R. Manniesing. "Stacked Bidirectional Convolutional LSTMs for 3D Non-contrast CT Reconstruction from Spatiotemporal 4D CT", in: Medical Imaging with Deep Learning. Abstract/PDF URL

  • R. Manniesing, M.T. Oei, L.J. Oostveen, J. Melendez, E.J. Smit, B. Platel, C.I. Sánchez, F.J. Meijer, M. Prokop and B. van Ginneken. "White Matter and Gray Matter Segmentation in 4D Computed Tomography", Nature Scientific Reports 2017;7(119). Abstract/PDF DOI PMID

  • M. Meijs, A. Patel, S. van de Leemput, M. Prokop, E.J. van Dijk, F.-E. de Leeuw, F.J.A. Meijer, B. van Ginneken and R. Manniesing. "Robust Segmentation of the Full Cerebral Vasculature in 4D CT Images of Suspected Stroke Patients", Nature Scientific Reports 2017;7. Abstract/PDF DOI PMID

  • A. Patel, B. van Ginneken, F.J.A. Meijer, E.J. van Dijk, M. Prokop and R. Manniesing. "Robust Cranial Cavity Segmentation in CT and CT Perfusion Images of Trauma and Suspected Stroke Patients", Medical Image Analysis 2017;36:216-228. Abstract/PDF DOI PMID

  • R. Manniesing, M.T.H. Oei, B. van Ginneken and M. Prokop. "Quantitative Dose Dependency Analysis of Whole-Brain CT Perfusion Imaging", Radiology 2016;278(1):190-197. Abstract/PDF DOI PMID

  • H.G.J. Kortman, E.J. Smit, M.T.H. Oei, R. Manniesing, M. Prokop and F.J.A. Meijer. "4D-CTA in Neurovascular Disease: A Review", American Journal of Neuroradiology 2015;36:1026-1033. Abstract/PDF DOI PMID