Publications of Bart Liefers

2022

PhD theses

1. B. Liefers, "Deep Learning Algorithms for Age-Related Macular Degeneration", PhD thesis, 2022.
   Abstract Url

2021

Papers in international journals

1. G. Bortsova, C. González-Gonzalo, S. Wetstein, F. Dubost, I. Katramados, L. Hogeweg, B. Liefers, B. van Ginneken, J. Pluim, M. Veta, C. Sánchez and M. de Bruijne, "Adversarial Attack Vulnerability of Medical Image Analysis Systems: Unexplored Factors", Medical Image Analysis, 2021:102141.
   Abstract DOI PMID arXiv Download Cited by ~28
2. J. Colijn, B. Liefers, N. Joachim, T. Verzijden, M. Meester-Smoor, M. Biarnés, J. Monés, P. de Jong, J. Vingerling, P. Mitchell, C. Sánchez, J. Wang, C. Klaver, E. Center and E. Consortium, "Enlargement of Geographic Atrophy From First Diagnosis to End of Life", JAMA Ophthalmology, 2021;139:743.
   Abstract DOI PMID Cited by ~12
3. B. Liefers, P. Taylor, A. Alsaedi, C. Bailey, K. Balaskas, N. Dhingra, C. Egan, F. Rodrigues, C. González-Gonzalo, T. Heeren, A. Lotery, P. Muller, A. Olvera-Barrios, B. Paul, R. Schwartz, D. Thomas, A. Warwick, A. Tufail and C. Sánchez, "Quantification of key retinal features in early and late age-related macular degeneration using deep learning", American Journal of Ophthalmology, 2021;226:1-12.
   Abstract DOI PMID Cited by ~29

Abstracts

1. C. González-Gonzalo, E. Thee, B. Liefers, C. de Vente, C. Klaver and C. Sánchez, "Hierarchical curriculum learning for robust automated detection of low-prevalence retinal disease features: application to reticular pseudodrusen", Association for Research in Vision and Ophthalmology, 2021.
   Abstract Url
2. C. González-Gonzalo, E. Thee, B. Liefers, C. Klaver and C. Sánchez, "Deep learning for automated stratification of ophthalmic images: Application to age-related macular degeneration and color fundus images", European Society of Retina Specialists, 2021.
   Abstract Url

2020

Papers in international journals

1. C. González-Gonzalo, B. Liefers, B. van Ginneken and C. Sánchez, "Iterative augmentation of visual evidence for weakly-supervised lesion localization in deep interpretability frameworks: application to color fundus images", IEEE Transactions on Medical Imaging, 2020;39(11):3499-3511.
   Abstract DOI PMID Cited by ~20
2. B. Liefers, J. Colijn, C. González-Gonzalo, T. Verzijden, J. Wang, N. Joachim, P. Mitchell, C. Hoyng, B. van Ginneken, C. Klaver and C. Sánchez, "A deep learning model for segmentation of geographic atrophy to study its long-term natural history", Ophthalmology, 2020;127(8):1086-1096.
   Abstract DOI PMID arXiv Cited by ~42

Preprints

1. G. Bortsova, C. González-Gonzalo, S. Wetstein, F. Dubost, I. Katramados, L. Hogeweg, B. Liefers, B. van Ginneken, J. Pluim, M. Veta, C. Sánchez and M. de Bruijne, "Adversarial Attack Vulnerability of Medical Image Analysis Systems: Unexplored Factors", arXiv:2006.06356, 2020.
   Abstract DOI arXiv Cited by ~4
2. P. Muller, B. Liefers, T. Treis, F. Gomes Rodrigues, A. Olvera-Barrios, B. Paul, N. Dhingra, A. Lotery, C. Bailey, P. Taylor, C. Sánchez and A. Tufail, "Reliability of retinal pathology quantification in age-related macular degeneration: Implications for clinical trials and machine learning applications", medrxiv, 2020.
   Abstract DOI Cited by ~13

Abstracts

1. A. Ardu, B. Liefers, C. de Vente, C. González-Gonzalo, C. Klaver and C. Sánchez, "Artificial Intelligence for the Classification and Quantification of Reticular Pseudodrusen in Multimodal Retinal Images", European Society of Retina Specialists, 2020.
   Abstract Url
2. B. Liefers, P. Taylor, C. González-Gonzalo, A. Tufail and C. Sánchez, "Achieving expert level performance in quantifying 13 distinctive features of neovascular age-related macular degeneration on optical coherence tomography", European Society of Retina Specialists, 2020.
   Abstract Url
3. C. González-Gonzalo, S. Wetstein, G. Bortsova, B. Liefers, B. van Ginneken and C. Sánchez, "Are adversarial attacks an actual threat for deep learning systems in real-world eye disease screening settings?", European Society of Retina Specialists, 2020.
   Abstract Url

2019

Papers in international journals

1. D. Valkenburg, E. Runhart, N. Bax, B. Liefers, S. Lambertus, C. Sánchez, F. Cremers and C. Hoyng, "Highly variable disease courses in siblings with Stargardt disease", Ophthalmology, 2019;126(12):1712-1721.
   Abstract DOI PMID Cited by ~17
2. T. Heesterbeek, E. de Jong, I. Acar, J. Groenewoud, B. Liefers, C. Sánchez, T. Peto, C. Hoyng, D. Pauleikhoff, H. Hense and A. den Hollander, "Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration", Scientific Reports, 2019;9(1):6611.
   Abstract DOI PMID Cited by ~20
3. J. Gómez-Valverde, A. Antón, G. Fatti, B. Liefers, A. Herranz, A. Santos, C. Sánchez and M. Ledesma-Carbayo, "Automatic glaucoma classification using color fundus images based on convolutional neural networks and transfer learning", Biomedical Optics Express, 2019;10(2):892-913.
   Abstract DOI PMID Cited by ~138
4. V. Schreur, A. Domanian, B. Liefers, F. Venhuizen, B. Klevering, C. Hoyng, E. de Jong and T. Theelen, "Morphological and topographical appearance of microaneurysms on optical coherence tomography angiography", British Journal of Ophthalmology, 2019;103(5):630-635.
   Abstract DOI PMID

Preprints

1. B. Liefers, J. Colijn, C. González-Gonzalo, T. Verzijden, P. Mitchell, C. Hoyng, B. van Ginneken, C. Klaver and C. Sánchez, "A deep learning model for segmentation of geographic atrophy to study its long-term natural history", arXiv:1908.05621, 2019.
   Abstract arXiv Cited by ~36
2. C. González-Gonzalo, B. Liefers, B. van Ginneken and C. Sánchez, "Iterative augmentation of visual evidence for weakly-supervised lesion localization in deep interpretability frameworks", arXiv:1910.07373, 2019.
   Abstract arXiv

Papers in conference proceedings

1. B. Liefers, C. González-Gonzalo, C. Klaver, B. van Ginneken and C. Sánchez, "Dense Segmentation in Selected Dimensions: Application to Retinal Optical Coherence Tomography", Medical Imaging with Deep Learning, 2019;102:337-346.
   Abstract Url Cited by ~11

Abstracts

1. H. van Zeeland, J. Meakin, B. Liefers, C. González-Gonzalo, A. Vaidyanathan, B. van Ginneken, C. Klaver and C. Sánchez, "EyeNED workstation: Development of a multi-modal vendor-independent application for annotation, spatial alignment and analysis of retinal images", Association for Research in Vision and Ophthalmology, 2019.
   Abstract Cited by ~1
2. B. Liefers, J. Colijn, C. González-Gonzalo, A. Vaidyanathan, H. van Zeeland, P. Mitchell, C. Klaver and C. Sánchez, "Prediction of areas at risk of developing geographic atrophy in color fundus images using deep learning", Association for Research in Vision and Ophthalmology, 2019.
   Abstract
3. C. González-Gonzalo, B. Liefers, A. Vaidyanathan, H. van Zeeland, C. Klaver and C. Sánchez, "Opening the "black box" of deep learning in automated screening of eye diseases", Association for Research in Vision and Ophthalmology, 2019.
   Abstract Url
4. D. Valkenburg, E. Runhart, B. Liefers, S. Lambertus, C. Sánchez, F. Cremers, B. Nathalie M and C. Hoyng, "Familial discordance in disease phenotype in siblings with Stargardt disease", Association for Research in Vision and Ophthalmology, 2019.
   Abstract

2018

Papers in international journals

1. F. Venhuizen, B. van Ginneken, B. Liefers, F. van Asten, V. Schreur, S. Fauser, C. Hoyng, T. Theelen and C. Sánchez, "A Deep Learning Approach for Detection and Quantification of Intraretinal Cystoid Fluid in Multivendor Optical Coherence Tomography", Biomedical Optics Express, 2018;9(4):1545-1569.
   Abstract DOI PMID Cited by ~117

Papers in conference proceedings

1. C. González-Gonzalo, B. Liefers, B. van Ginneken and C. Sánchez, "Improving weakly-supervised lesion localization with iterative saliency map refinement", Medical Imaging with Deep Learning, 2018.
   Abstract Url Cited by ~4

2017

Papers in international journals

1. B. Liefers, F. Venhuizen, V. Schreur, B. van Ginneken, C. Hoyng, S. Fauser, T. Theelen and C. Sánchez, "Automatic detection of the foveal center in optical coherence tomography", Biomedical Optics Express, 2017;8(11):5160-5178.
   Abstract DOI PMID Cited by ~30
2. F. Venhuizen, B. van Ginneken, B. Liefers, Schreur, M. van Grinsven, S. Fauser, C. Hoyng, T. Theelen and C. Sánchez, "Robust Total Retina Thickness Segmentation in Optical Coherence Tomography Images using Convolutional Neural Networks", Biomedical Optics Express, 2017;8(7):3292-3316.
   Abstract DOI PMID Cited by ~114

Papers in conference proceedings

1. B. Liefers, F. Venhuizen, T. Theelen, C. Hoyng, B. van Ginneken and C. Sánchez, "Fovea Detection in Optical Coherence Tomography using Convolutional Neural Networks", Medical Imaging, 2017;10133:1013302.
   Abstract DOI Cited by ~4

Abstracts

1. B. Liefers, F. Venhuizen, V. Schreur, B. van Ginneken, C. Hoyng, T. Theelen and C. Sánchez, "Automatic detection of the foveal center in optical coherence tomography", Association for Research in Vision and Ophthalmology, 2017.
   Abstract
2. F. Venhuizen, S. Schaffhauser, V. Schreur, B. Liefers, B. van Ginneken, C. Hoyng, T. Theelen, E. de Jong and C. Sánchez, "Fully automated detection of hyperreflective foci in optical coherence tomography", Association for Research in Vision and Ophthalmology, 2017.
   Abstract
3. J. Gomez, C. Sánchez, B. Liefers, F. Venhuizen, G. Fatti, A. Morilla-Grasa, Y. Cartagena, A. Cabarcos, A. Santos, M. Ledesma-Carbayo and A. Anton-Lopez, "Automated Analysis of Retinal Images for detection of Glaucoma based on Convolutional Neural Networks", Association for Research in Vision and Ophthalmology, 2017.
   Abstract Cited by ~2

2016

Abstracts

1. B. Liefers, V. Schreur, T. Theelen and C. Sánchez, "Registration and grading of micro-aneurysms in Fluorescein Angiography and OCT Angiography", 4th International Congress on OCT Angiography and Advances in OCT, 2016.
   Abstract