Vitamin K-dependent proteins are involved in (patho)physiological calcification of the vasculature and the bones. Type 2 diabetes mellitus (DM2) is associated with increased arterial calcification and increased fractures. This study investigates the effect of 6 months vitamin K2 supplementation on systemic arterial calcification and bone mineral density (BMD) in DM2 patients with a history of cardiovascular disease (CVD).
Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2
J. Bartstra, F. Draaisma, S. Zwakenberg, N. Lessmann, J. Wolterink, Y. van der Schouw, P. de Jong and J. Beulens
European Journal of Nutrition 2021;60:1691-1699.