Prediction of prostate cancer grade using fractal analysis of perfusion MRI: retrospective proof‑of‑principle study

F. Michallek, H. Huisman, B. Hamm, S. Elezkurtaj, A. Maxeiner and M. Dewey

European Radiology 2021.


Multiparametric MRI has high diagnostic accuracy for detecting prostate cancer, but non-invasive prediction of tumor grade remains challenging. Characterizing tumor perfusion by exploiting the fractal nature of vascular anatomy might elucidate the aggressive potential of a tumor. This study introduces the concept of fractal analysis for characterizing prostate cancer perfusion and reports about its usefulness for non-invasive prediction of tumor grade.