AI-driven detection and characterization of incidental lung nodules

Background

Lung cancer is often diagnosed in a late stage, and as a result, the 5-year survival rate for lung cancer is only 18%. If lung cancer is detected in an early stage, the prognosis is much better. Therefore, improving early detection is the most promising strategy to reduce lung cancer mortality.

Early stage lung cancer is typically diagnosed after the detection of an incidental lung nodule on CT imaging of the thorax that was ordered for other medical reasons. For this reason, accurate detection and characterization of incidentally detected lung nodules is of great importance.

Aim

In this project, we aim to develop artificial intelligence (AI) algorithms for fast and highly reliable detection and assessment of nodules in chest CT, and to validate the novel AI-assisted nodule workflow at two Dutch hospitals.

Funding

This project is funded by a Radboud Institute for Health Sciences Junior Researcher grant, with funding coming from Radboudumc and Jeroen Bosch Ziekenhuis in 's-Hertogenbosch.

People

Ward Hendrix

Ward Hendrix

Research Scientist RTC Deep Learning

RTC Deep Learning

Colin Jacobs

Colin Jacobs

Associate Professor

Matthieu Rutten

Matthieu Rutten

Associate Professor, Radiologist

Bram van Ginneken

Bram van Ginneken

Professor, Scientific Co-Director

Publications

  • W. Hendrix, N. Hendrix, E. Scholten, M. Mourits, J. Trap-de Jong, S. Schalekamp, M. Korst, M. van Leuken, B. van Ginneken, M. Prokop, M. Rutten and C. Jacobs, "Deep learning for the detection of benign and malignant pulmonary nodules in non-screening chest CT scans", Communications Medicine, 2023;3(1):156.
  • W. Hendrix, M. Rutten, N. Hendrix, B. van Ginneken, C. Schaefer-Prokop, E. Scholten, M. Prokop and C. Jacobs, "Trends in the incidence of pulmonary nodules in chest computed tomography: 10-year results from two Dutch hospitals", European Radiology, 2023;33:8279-8288.
  • W. Hendrix, N. Hendrix, M. Prokop, E. Scholten, B. Van Ginneken, M. Rutten and C. Jacobs, "Trends in the Incidence of Pulmonary Nodules in Chest Computed Tomography: 10-Year Results from Two Dutch Hospitals", European Congress of Radiology, 2021.